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. 2017 Nov 28;5(3):223–237. doi: 10.1016/j.jcmgh.2017.11.011

Figure 7.

Figure 7

Bile acid levels and composition are unchanged after 5 days of oral clofazimine treatment. (A–D) Bile acid composition in bile, feces, urine, and plasma of mice orally gavaged with placebo, 25 mg/kg clofazimine (low dose), or 75 mg/kg clofazimine (high dose). (E–G) Bile acid concentration in (E) blood plasma and (F) urine, or (G) total fecal bile acid output of mice treated with placebo, a high dose, or a low dose of clofazimine for 5 days. Bile acid composition is expressed as a percentage of total bile acid concentration (μmol/L). Data are represented as means ± SD. *P < .05, n = 15 mice per group (1-way analysis of variance; post hoc: Dunnett multiple comparison). αMC, alpha muricholate; BA, bile acids; βMC, beta-muricholate; CA, cholic acid; DC, deoxycholate; GCDC, glycochenodeoxycholic acid; omega-muricholate (ΩMC)TαMC, tauro-alpha muricholate; TβMC, tauro-beta muricholate; TCA, taurocholic acid; TC, Taurocholate; TDC, Taurodeoxycholic acid.