Skip to main content
. 2017 Dec 15;23(3):393–398. doi: 10.1007/s12192-017-0849-y

Fig. 4.

Fig. 4

IRF-8 regulates the expression of MMP-13 at the transcriptional level. Null, empty virus; Lentiviral-IRF-8, IRF-8 overexpression group. NS, no specific small RNA interference; IRF-8 siRNA, IRF-8 specific small RNA interference. a Primary chondrocytes were transducted with lentiviral-IRF-8. Western blot analysis revealed the successful overexpression of IRF-8 (**P < 0.01 vs. EV group); b Western blot analysis revealed that overexpression of IRF-8 exacerbated IL-1β-induced expression of MMP-13 (**P < 0.01 vs. EV group; #P < 0.01 vs. IL-1β treatment group); c Primary chondrocytes were transfected with IRF-8 siRNA. Western blot analysis revealed the successful knockdown of IRF-8 (**P < 0.01 vs. NS group); d Western blot analysis revealed that knockdown of IRF-8 inhibited IL-1β-induced expression of MMP-13 (**P < 0.01 vs. NS group; #P < 0.01 vs. IL-1β-treated group)