Fig. 2.

Hypothetical model for export of small heat shock proteins (sHsps) into the extracellular medium. sHsps may be part of the ESCRT-I complex and involved in the biogenesis of exosomes by directly interacting with Tsg101, an important component of the ESCRT-I machinery, and they might also act as a branch point to decide the fusion of MVBs with plasma membrane or lysosome