Table 3.

Clinical features of 33 Carney Complex patients reported in Japan

Clinical features	No. of patients	%
Age	mean, 30.3 years (range; 3-73 years)
with PRKAR1A mutation	mean, 26.6±20.2 (n=7)
without PRKAR1A mutation	mean, 64.3±11.7 (n=3)
not available	mean, 27.0±15.5 (n=23)
Gender
Male	7	21
Female	26	79
Family history
yes	13	39
no	20	61
Chief complaints
subcutaneous or beast tumor	9	27
pigment deposition of the skin	8	24
Cushing sign	11	33
others	1	3
no symptom	4	12
Clinical manifestations
spotty skin pigmentation	16	49
cardiac myxoma	14	42
cutaneous myxoma	13	39
primary pigmented nodular adrenocortical disease (PPNAD)	17	52
large-cell calcifying Sertoli cell tumor or steroid-type tumor or both	1	3
mammary myxomatosis or fibroadenoma	7	21
pituitary adenoma (acromegaly)	13	39
thyroid tumors	5	15
osteochondromyxoma	0	0
psammomatous melanotic schwannoma	0	0
blue nevus	0	0
Operation history
none	6	18
once	15	46
twice	6	18
more than three times	6	18