Table 1.
Patient demographics
| Characteristic | CBT (n = 8) | SSRI (n = 8) | ||
|---|---|---|---|---|
| Age, y | ||||
| Mean (SD) | 33.7 (9.5) | 33.4 (8.5) | ||
| Range | 23–53 | 18–45 | ||
| Responders/partial responders | 4/8 | 6/8 | ||
| Early-onset OCD (≤10 y), No. | 5 | 5 | ||
| Predominant compulsion, No. | ||||
| Washing | 4 | 4 | ||
| Checking | 4 | 4 | ||
| Lifetime history of MDE (2° to OCD symptoms), No. | 2 | 3 | ||
| Past substance abuse, No. | 0 | 0 | ||
| Pre | Post | Pre | Post | |
| Y-BOCS score, mean (SD) | 23 (4.4) | 15.8 (7.5) | 23.6 (5.6) | 14.7 (8.2) |
| BDI score, mean (SD) | 9.8 (4.5) | 6.9 (6.0) | 14.1 (11.2) | 7.6 (9.5) |
| Plasma free tryptophan, mean (SD), nmol/La | 10.3 (2.6) | 8.4 (1.4) | 9.8 (1.7) | 9.3 (2.1) |
| Global K*, mean (SD), mL/g/mina | 5.1 (1.3) | 6.1 (1.5) | 5.8 (1.3) | 6.07 (2.0) |
| Intravenously injected, mean (SD), mCia | 9.3 (1.1) | 9.6 (0.7) | 9.6 (0.8) | 9.7 (0.4) |
Responders/partial responders demonstrated a >25% decrease in Y-BOCS score
OCD obsessive-compulsive disorder, CBT cognitive behavioral therapy, SSRI selective serotonin re-uptake inhibitor, MDE major depressive episode, Y-BOCS Yale-Brown Obsessive Compulsive Scale, BDI Beck Depression Inventory, No. number
aData not included for one patient treated with CBT