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. 2018 Apr 17;9:1513. doi: 10.1038/s41467-018-03986-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — AKT1 signaling in myeloid cells confers resistance to T. cruzi infection. a Survival rate of littermate control (n = 7) and Akt1^−/−Lysm^cre (n = 7) mice after infection with 10³ trypomastigote forms of T. cruzi Y strain. b Quantitative PCR analysis of picogram of T. cruzi DNA presents in 1 ng of heart tissue DNA isolated from WT (n = 5) and Akt1^−/−Lysm^cre (n = 5) mice. c Survival rate of WT (n = 7) and AKT2^−/− (n = 7) mice infected with 10³ trypomastigote forms of T. cruzi Y strain. *P < 0.05 and ns = no statistical significance (Mantel–Cox log-rank test in a, c and unpaired Student’s t-test in b). Data are representative of two independent experiments (mean ± s.e.m in b)