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. 2018 Apr 17;8:6065. doi: 10.1038/s41598-018-24531-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Murine CD4⁺CD25⁺ dTregs express high levels of specific miRNAs compared to CD11c⁺ BM-DCs. (A) Microarray heat map diagram showing a two-way unsupervised hierarchical clustering of miRNAs by CD4⁺CD25⁺ dTregs and BM-DCs microRNA. (B) Bar graphs (mean+SEM) showing the relative quantity (RQ) of miR-125b-5p, miR-150-5p, and miR-182-5p in BM-DCs and dTregs, as measured by qPCR and normalised relative to RNU6-2 and SCARNA17. Data represents 2 individual experiments that were performed in duplicates. Statistical significance was determined using a two-tailed paired Student’s t-test where **p < 0.01 and ***p < 0.001. (C) Bar graphs (mean + SEM) showing the RQ of indicated miRNAs by Tregs immediately before (no act) and after (+act) polyclonal stimulation with anti-CD3/CD28 beads, as measured by qPCR and normalised relative to RNU6-2 and SCARNA17.