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. 2018 Apr 17;9:1508. doi: 10.1038/s41467-018-03937-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Metabolism of a methanol-essential Escherichia coli strain. The introduced synthetic pathway is depicted in orange and comprises methanol dehydrogenase (Mdh), 3-hexulose-6-phosphate synthase (Hps), and 6-phospho-3-hexuloisomerase (Phi). Identified knockouts leading to methanol essentiality in the case of gluconate as a carbon source are shown in red; phosphogluconate dehydratase (edd) and ribose-5-phosphate isomerase (rpiAB). The knockout for reducing TCA cycle activity and mimicking natural methylotrophs is shown in blue; here malate dehydrogenase (maldh). Names and abbreviations are given according to the Biocyc database (http://www.biocyc.org)