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. 2018 Apr 17;8:6114. doi: 10.1038/s41598-018-24525-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cardiac contractile function 12 weeks post-MI was better preserved in dn-c-kit-Tg (Tg) relative to NTL hearts. (a) EF was greater in P196 Tg sham (n = 15) and post-MI hearts (n = 16) relative to NTL controls (n = 9), and post-MI loss of ejection fraction was less in Tg than in NTL hearts, relative to respective sham controls; differences analysed by ordinary one-way ANOVA with Tukey’s multiple comparison test. (b) Single beat PRSW slopes indicate contractility was greater in P196 Tg sham (n = 15) and post-MI (n = 16) hearts relative to NTL (n = 8–9) hearts, and post-MI loss of contractility of Tg hearts was less than that of NTL hearts relative to their respective sham controls; differences analysed by ordinary one-way ANOVA with Tukey’s multiple comparison test. (c) dP/dt_max normalised to LVEDV was greater in P196 sham Tg (n = 15) relative to NTL (n = 8) hearts and in post-MI Tg (n = 16) relative to NTL (n = 9) hearts; differences analysed by Student’s t-test.