Table 5.
Histology of NTL and dn-c-kit-Tg hearts three months after sham operation or myocardial infarction (age P196).
| Parameter | NTL sham (n) | NTL MI (n) | Tg sham (n) | Tg MI (n) |
|---|---|---|---|---|
| Percent fibrosis | 0.9 ± 0.01 (5) | 1.1 ± 0.2 (7) | 0.8 ± 0.1 (5) | 1.2 ± 0.3 (9) |
| Capillary density in remote zone (capillaries/mm2) | 3329 ± 332 (6) | 3340 ± 445 (8) | 2967 ± 230 (6) | 3673 ± 577 (8) |
| Capillary density/CM | 1.54 ± 0.09 (6) | 1.47 ± 0.1 (8) | 1.49 ± 0.06 (6) | 1.54 ± 0.07 (8) |
| Mean intercapillary distance (μm) | 0.03 ± 0.002 (6) | 0.03 ± 0.001 (8) | 0.03 ± 0.001 (6) | 0.03 ± 0.002 (8) |
| TUNEL staining | 0 (3) | 0 (3) | 0 (3) | 0 (3) |
Data are presented as mean ± SEM. n, number of animals. Ordinary one-way ANOVA with Tukey’s multiple comparisons tests: *p < 0.05, **p < 0.01, ***p < 0.001 MI mice vs their respective sham-operated controls and †p < 0.05, ††p < 0.01, †††p < 0.001, NTL vs Tg mice. CM, cardiomyocyte.