Table 2.

Association between baseline CRMP1, GSK3β, AKT1, and PKCε mRNA levels and severity of mood symptoms

	YMRS			MADRS
	β	95% CI	P	β	95% CI	P
GSK3β (N = 38)
Unadjusteda	2.84	0.36–5.27	<0.02	0.89	−2.35–4.14	<0.60
Adjusteda,b	2.81	0.60–5.51	<0.02	0.76	−2.46–3.99	<0.70
CRMP1 (N = 35)
Unadjusteda	0.45	0.11–0.79	<0.02	0.34	−0.10–0.79	<0.20
Adjusteda,b	0.48	0.13–0.84	<0.009	0.38	−0.05–0.80	<0.09
AKT1 (N = 37)
Unadjusted	1.24	−0.76–3.24	<0.30	1.15	−1.76–4.06	<0.30
Adjustedb	1.39	−0.69–3.47	<0.20	1.35	−1.66–4.35	<0.40
PKCε (N = 36)
Unadjusted	−0.38	−1.93–1.17	<0.70	−1.1	−2.42–0.22	<0.10
Adjustedb	−0.25	−1.72–1.23	<0.80	−0.94	−2.34–0.46	<0.20

CI confidence interval

^aSignificant association between the baseline normalized expression levels and severity of mood symptoms

^bAdjusted for differences in age and sex, and education for all subjects for the different targeted genes