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. 2018 Apr 17;9:1514. doi: 10.1038/s41467-018-03803-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Activation of cell metabolism and global gene expression by combined stimulation of P493-6 cells with IL10 and CpG. a Heat map of changes in intracellular metabolite concentrations depicted as Log2FC after IL10 and/or CpG stimulation of P493-6 MYC^low cells in relation to unstimulated cells. Heat map of gene expression changes associated with b glycolysis (KEGG-term) and c glutaminolysis (KEGG-term), respectively, after IL10 and/or CpG stimulation of P493-6 MYC^low cells presented as Log2FC. Mean of three independent experiments is shown in all heat maps. Effects on gene expression were analyzed by linear regression and p-values for the IL10:CpG interaction terms were calculated (adjusted by Benjamini–Hochberg). Positive synergistic interactions are marked with a star (*p < 0.05). Relative cell counts of d IL10 + CpG-stimulated P493-6 MYC^low cells and e unstimulated P493-6 MYC^high cells grown in media with and without either glucose (–Glc) or glutamine (–Gln). Mean ± SD of three independent experiments are given