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. 2018 Apr 17;9:1503. doi: 10.1038/s41467-018-03922-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Phase set enrichment analysis of the genes with oscillating TCR. Cumulative distributions (to 100%) of the genes associated with a Photosynthesis, light harvesting and b Cell maturation categories (orange). The cumulative distributions are significantly different from the background (1453 genes with TCR oscillation, blue) based on the Kuiper test (q < 0.05). c Phase values of the genes involved in specific pathways. Each vertical bar represents a gene phase value which is aligned with the x-axis. Orange points represent the median phase values of the genes for each category