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. 2018 Apr 17;8:6130. doi: 10.1038/s41598-018-24439-3

Figure 5.

Figure 5

Synthetic 9CBC rescues S- and M-cones from degeneration in eye cup cultures of RPE65rd12 retina. Eye cups of 21 day old RPE65Rd12 mice were incubated in media supplemented with 1 μM synthetic 9CBC (4 eye cups, panels B & D) or same concentration of vehicle solution (3 eye cups, panels A & C) for 18 hours. Eye cups were fixed and sections were stained with antibodies directed against S-cone opsin (green, marked with white arrows, panel A, B) or M-cone opsin (green, marked with white arrows, panels C, D) and counter stained with DAPI (blue). (E) Number of positively stained cells per section was recorded and data are presented as mean ± standard error.