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. 2018 Apr 17;8:6081. doi: 10.1038/s41598-018-24274-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of prednisolone and vamorolone on nociception. Data are presented as means and standard errors of percentage changes from baseline by genotype and treatment for hot plate (A) and tail flick latencies (B), current thresholds in response to 2000 (C), 250 (D) or 5 Hz (E) stimulations. Hetero indicates heterozygotes and homo homozygotes (N = 13–18 per each of 9 treatment groups for all outcome measurements). Regardless of genotype and sex, six-week treatment with vehicle, prednisolone, or vamorolone yielded similar percent changes from baseline on hot plate and tail flick latencies and on current thresholds in response to 2000 or 5 Hz stimulations (all p > 0.05, A,B,C and E). Regarding 250 Hz current thresholds, the effects of prednisolone and vamorolone, compared with vehicle, varied according to genotype as there was a significant treatment*genotype interaction (p = 0.014) although neither the main effect of treatment or genotype reached statistical significance (p = 0.07 and p = 0.18, respectively, (D). As shown in (D), the pattern of percent change from baseline over treatment groups is markedly different for each genotype.