Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 17;8:6081. doi: 10.1038/s41598-018-24274-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effect of prednisolone and vamorolone on liver function tests and malondialdehyde levels. Data are presented as means and standard errors of alanine aminotransferase (ALT, A), aspartate aminotransferase (AST, B), alkaline phosphatase (ALK, C), and malondialdehyde (D). Hetero indicates heterozygotes and homo homozygotes (N = 5–7 per each of 9 treatment groups for all outcome measures). Among vehicle-treated mice, compared with controls, homozygotes had significantly higher plasma levels of ALT (p < 0.001, A), AST (p = 0.001, B), and ALK (p < 0.001, C). Overall, the effects of vamorolone and prednisolone on ALK, ALT, and AST were similar (p = 0.071, p = 0.27, p = 0.40 respectively). Additionally, independent of genotype, compared with vehicle, vamorolone and prednisolone treatment was associated with increased ALK and AST (p = 0.018 and p = 0.042 respectively for main treatment effect). (D) Homozygotes had higher levels of liver malondialdehyde formation compared with control and heterozygous mice (p < 0.001). Additionally, independent of genotype, there was no effect of treatment on malondialdehyde formation in liver homogenates (p = 0.66).