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. 2018 Apr 18;8:85. doi: 10.1038/s41398-018-0132-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representative action potential trains in WT (left panel) and Df(16)A^+/− neurons (middle panel) at DIV7 (upper panel) and DIV14 (lower panel), in response to a 500 ms depolarizing 100 pA current step from −60 mV. A close up of the WT (blue trace) vs. Df(16)A^+/− neuron (red trace) action potential waveforms overlaid (right panel) at both DIV7 and DIV14. b Quantitative data of overshoot (AP amplitude) in WT and Df(16)A^+/− cortical neurons at DIV7 and DIV14, respectively. Df(16)A^+/− cortical neurons showed significant decrease in overshoot at DIV7 compared to WT neurons (t test, *p < 0.05). c Quantitative data of half width (AP duration) in WT and Df(16)A^+/− cortical neurons at DIV7 and DIV14, respectively. There was no significant difference between genotypes at both time points. (d) Quantitative data of rising rate in WT and Df(16)A^+/− cortical neurons at DIV7 and DIV14, respectively. Df(16)A^+/− cortical neurons showed significant decrease in rising rate at DIV7 compared to WT neurons (t test, * p < 0.05). e Quantitative data of decay rate in WT and Df(16)A^+/− cortical neurons at DIV7 and DIV14, respectively. There was no significant difference between genotypes at both time points. f At DIV7, Df(16)A^+/− neurons (red) fired more action potentials than did WT neurons (blue) in response to large current injections for 500 ms when resting membrane potential was adjusted to −60 mV (2-way repeated measures ANOVA, genotype × current: *p < 0.05. Bonferroni post tests showed significant genotypic differences at current injections of 150, 160, 170, 180 and 200 pA). g At DIV14, Df(16)A^+/− neurons (red) fired more action potentials compared to WT neurons (blue) in response to large current injections for 500 ms when resting membrane potential was adjusted to −60 mV (2-way repeated measures ANOVA, genotype × current: *p < 0.05. Bonferroni post tests showed no significant difference at single current steps)