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. 2018 Apr 17;8:6103. doi: 10.1038/s41598-018-24213-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Microarray gene expression analysis of SERT KO ileal mucosa. Gene expression in the ileal mucosa of 6 WT and 6 SERT KO mice was analyzed by microarray analysis as described in Methods. (a) Heat map showing the result of unsupervised hierarchical clustering of selected differentially expressed genes between WT and SERT KO. (b) Volcano plot showing the distribution of differentially expressed genes with cutoff criteria of log2|fold-change| ≥ 0.585 and a p-value < 0.05. Up-regulated genes shown in red and down-regulated genes shown in green. (c) List of selected genes that were significantly up-regulated or down-regulated in SERT KO mouse ileal mucosa. Full list of differentially expressed genes available at GEO (accession GSE93534).