Table 1.

Annual percent change of the incidence for MACs in different sites by era/SEER Database.

	1973–1980	P-Value	1981–1999	P-Value	2000–2014	P-Value	1973–2014	P-Value
Primary sites
Stomach	−21.5	*	−2.1	*	−4.7	*	−5.2	*
Appendix	−2.9		5.4	*	6.3	*	4.9	*
Cecum	−13	*	3.3	*	−5.6	*	−0.3
Colona	−11.8	*	3.4	*	−5.4
Rectum	−13.6	*	3.4	*	−5.9	*	−1.3	*
Breast	−5.1	*	3	*	−3.3	*	0.4
Ovary	−8.9		3.1		−0.8		0.6	*
Uterus	−16	*	8.6	*	−5	*	1.2
Lung and Bronchus	−16.9	*	5.1	*	4.8	*	1.2	*
Pancreas	−14.5		3.2	*	−3.3	*	−0.2
All sites	−12.2	*	3.3	*	−3.4	*	−0.1
Disease stage
Localized	−7.8	*	4.5	*	−2.8	*	0.9	*
Regional	−11.7	*	3.4	*	−5.0	*	−0.3
Distant	−13.9	*	2.7	*	−2.3	*	−0.4

^aColon excluding appendix and cecum *P < 0.05.