Fig. 3.

Promoter Capture Hi–C enables refinement of the BMI GWAS locus that colocalizes with cis-eQTLs interacting with the target gene promoter of MAP2K5. Genomic landscape of the BMI locus, MAP2K5 (panels a, b), modified from the WashU Genome Browser to show the histone mark calls from ChIP-seq data; gene transcripts; promoter and eQTL HindIII fragments that interact in primary human white adipocytes (HWA); and GWAS SNPs (A, the rs number indicated in the magnified box) or their LD proxies (B, r² > 0.8) located in the interacting HindIII fragment. The vertical yellow band highlights the cis-eQTL variant (the rs number is indicated in the magnified box). a Genomic landscape containing MAP2K5 and the interacting cis-eQTL variant and corresponding BMI GWAS SNP. b Magnification of the boxed region in (a)