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. 2018 Apr 17;8:6112. doi: 10.1038/s41598-018-24394-z

Figure 2.

Figure 2

Longevity of the cross-reactive CD4 T cell response. Naïve ferrets were infected intranasally with H1N1pdm09 strain, A/NY/21/2009 (H1N1pdm09, n = 7), or were mock infected (Mock; n = 6). Peripheral blood leukocytes were purified weekly for 6 weeks, and T cell responses assessed by stimulation with a panel of live influenza strains (A). Splenocytes were collected 6 weeks post-infection and stimulated with the panel of live influenza strains (B). Responding CD4 T cells were assessed for IFN-γ production by flow cytometry. Significance from the mock infected group is indicated by *p < 0.05, ∇p < 0.01, †p < 0.001. Error bars represent SEM.