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. 2018 Apr 11;9:735. doi: 10.3389/fimmu.2018.00735

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Copyright © 2018 Nanthapisal, Eleftheriou, Gilmour, Leone, Ramnath, Omoyinmi, Hong, Klein and Brogan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Cutaneous vasculitis over both lower extremities of the index case [V-2; (C)]. (B) Skin biopsy of the lesion showing a dermal perivascular and interstitial infiltrate of predominantly neutrophils and nuclear dust which is compatible with leukocytoclastic vasculitis (haematoxylin & eosin stain, high magnification). (C) Family pedigree. (D) Sanger sequencing confirmed a homozygous G/G mutation (single black line) at position 1,139 of complement factor I gene in the index case and the asymptomatic brother; a heterozygous A/G state (Green/black line) was confirmed in both parents.