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Reactions involved in chromophore regeneration in rod and cone photoreceptors. Rod pigment regeneration is limited to the canonical pathway where RPE65 isomerises 11-cis-RAL from RE. Isomerization occurs independently of RPE65 in the cone specific pathway, involving the Müller glia. CRALBP is thought to be the primary 11-cis retinoid carrier in both pathways.
