Fig. 2.

Timeline of the clinical history in patients with CAA: The top row indicates the age in years and the two left columns denote all four patients in our study and reports from the literature, with the patient identifier used in the text. In the timeline, light orange indicates the period prior to neurosurgery; light purple the intervals between neurosurgery and CAA diagnosis or first episode of intracerebral haemorrhage. The green lines on the left indicate the time points of neurosurgical interventions. In patient #5, the time point indicating surgery is an estimate. In patients #6 and #7, the purple lines indicate an estimated time point of head trauma. The red lines on the right indicate the age at which the haemorrhage(s) occurred and the black line indicates the age at death. ApoE status for each patient, where available, is indicated in the far right column (NA not available). Patient #9 [49] did not have neurosurgery and no clinical information of surgery is available for patient #10 [8]