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a The mean arterial blood pressure of anaesthetized mice decreased significantly 10 min after adhesion of a GTN patch to the abdomen (red), but not after control adhesive tape (blue). **P < 0.01 by paired T test. b–d In mice treated with a GTN patch, plasma nitrite (NO2−) concentration was significantly elevated after 10 min (*P < 0.05 by unpaired T test). The difference in plasma nitrate (NO3−) and total nitrates and nitrites was not significant
