Table 1.
Overview of TCGA, French GWAS and French seq series and mutation status of tumours
Dataset | Controls | Cases (GBM/non-GBM) | Case groupings | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IDH status | EGFR | CDKN2A | Molecular subgroup | WHO 2016 classification | ||||||||||||||||
mut | wt | amp | wt | del | wt | IDH-only | TERT-IDH | TERT-only | Triple −ve | Triple +ve | Total | AstroIDH-mut | Astro IDH-wt | Oligo 1p19q | GBM IDH-mut | GBM IDH-wt | Total | |||
TCGA | 2648 | 521 (183/338) | 293 | 228 | 246 | 270 | 254 | 262 | 100 | 4 | 45 | 10 | 65 | 224 | 166 | 51 | 116 | 10 | 171 | 514 |
French GWAS | 1190 | 1423 (430/993) | 366 | 498 | 118 | 628 | 173 | 573 | 169 | 46 | 309 | 141 | 85 | 750 | 188 | 214 | 95 | 27 | 233 | 757 |
French seq | 5527 | 704 (181/523) | 427 | 277 | 101 | 592 | 144 | 549 | 181 | 28 | 185 | 92 | 199 | 685 | 178 | 114 | 218 | 31 | 148 | 689 |
Total | 9365 | 2648 (795/1854) | 1086 | 1003 | 465 | 1490 | 571 | 1384 | 450 | 78 | 539 | 243 | 349 | 1659 | 532 | 379 | 429 | 68 | 552 | 1960 |
Amp amplified, astro astrocytoma, del deleted, mut mutated, oligo oligodendroglioma, wt wildtype