Table 1.

SNP-based heritability (h²g) for EHR-based bipolar disorder from the Partners Healthcare Research Patient Data Registry

Bipolar disorder algorithms	h2g (SE)				Sample size
	Liability scale	Observed scale	P-valueb	PPV	cases	controls
95-NLP	0.24 (0.10)	0.25 (0.10)	0.015	0.86	862	3952
Coded-strict	0.09 (0.05)	0.15 (0.08)	0.064	0.84	1968	3952
Coded-broad	0.13 (0.04)	0.22 (0.08)	0.003	0.80	2581	3952
Coded-broad-SV	0.00 (0.11)	0.00 (0.18)	0.591	0.50	408	3952
All except coded-broad-SV	0.12 (0.04)	0.21 (0.07)	0.004	0.83	3013	3952
ICCBD + PGCBDa	0.23 (0.01)	0.41 (0.02)	3.17 × 10−80	NA	13902	19279

SNP-based heritability on liability scale was converted from observed scale based on population prevalence of 1%

^aICCBD + PGCBD: Bipolar disorder genome-wide association study from the ICCBD and PGC1 with cases ascertained by traditional methods (Charney et al.⁷)

^bTest for h²_g different from 0. PPV: positive predictive values from clinical validation (Castro et al.¹⁰). 95-NLP: probabilistic algorithm with 95% specificity based on natural language processing. Coded-strict, Coded-broad, Coded-broad-SV: coded rule-based algorithms with decreasing stringency. SV: single visit. SE: standard error