Table 2.

Relative expression of angiocrine proteins upon TNF-α or hypoxia in cell culture.

Gene	Protein	GDS2773	GDS2773	GDS1543	GDS1968	GDS1968	GDS1968	GDS1968	GDS1968
		mouse EC	mouse EC	HMEC	HUVEC	HUVEC	HUVEC	HUVEC	HUVEC
		TNF acute	TNF chronic	TNF	1 h hypox	3 h reox	5 h reox	12 h reox	24 h reox
Tnc	Tenascin C			4.8	2.1	2.3
Thbs1	Thrombospondin 1	13.4			0.6			0.6
Fstl1	Follistatin-like 1	2.1
Ctgf	Connective tissue growth factor	4.5				0.4		0.7
Ptgis	Prostaglandin I2 synthase				0.6			0.5
Bmp2	Bone morphogenetic protein 2				0.7
Apln	Apelin				0.6
Thbs2	Thrombospondin 2				4.7	3.9	4.7	3
Thbs3	Thrombospondin 3				1.6
Il1b	Interleukin 1 beta			4.1
Pgf	Placental growth factor				1.4
Lif	leukemia inhibitory factor		3.2		1.5	2.5
Tnxb	Tenascin XB								1.7
Wisp1	WNT1 inducible signaling pathway protein 1					0.6	0.5	0.5
Mdk	Midkine				1.5

Relative expression of angiocrine proteins in ECs after acute or chronic stimulation with TNF-α, after 1 h ischemia, or after different time points of reoxygenation. All experiments are based on in vitro EC culture and all values are compared to control samples (non-stimulated or non-ischemic). Only statistically significant differences are shown.