Table 3.
Relative expression of angiocrine proteins in models of cardiac overload or compared to other cell types.
| Gene | Protein | A | B | C | D | E | F | G | H | I | J | K | L |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GSE45820 | GDS1402 | GDS1402 | GDS3661 | GDS1264 | GDS3288 | GDS3655 | GDS2145 | GDS2542 | GDS2206 | GDS2424 | GDS2154 | ||
| Mouse | Human | Human | Rat | Rat | Mouse | Mouse | Rat | Mouse | Human | Dog | Human | ||
| TAC | vs. fibro | vs. SMC | AHT HF | AHT HF | Apelin KO | ICMP | ICMP | Obesity HF | DCMP | Pacing HF | Myocarditis | ||
| Il6 | Interleukin 6 | 93.4 | 1.5 | 0.5 | 0.6 | ||||||||
| Postn | Periostin | 46.7 | 0.2 | 11.5 | 6.3 | 3.4 | 3.7 | ||||||
| Tnc | Tenascin C | 24.5 | 0.2 | ||||||||||
| Thbs1 | Thrombospondin 1 | 24.1 | 8.7 | 6.1 | 0.4 | 3.8 | 3.1 | ||||||
| Fstl1 | Follistatin-like 1 | 12.6 | 1.9 | 2.0 | 2.6 | 0.9 | 0.6 | ||||||
| Frzb | Frizzled-related protein 3 | 9.7 | 0.3 | 0.5 | 4.7 | 2.3 | |||||||
| Thbs4 | Thrombospondin 4 | 9.5 | 31.2 | 3.6 | 0.5 | 1.5 | |||||||
| Igf1 | Insulin-like growth factor 1 | 9.1 | 1.1 | ||||||||||
| Ctgf | Connective tissue growth factor | 8.7 | 1.9 | 1.3 | 3.1 | 1.4 | |||||||
| Ptgis | Prostaglandin I2 synthase | 7.4 | 0.07 | 0.2 | 2.1 | 1.6 | |||||||
| Dkk3 | Dickkopf homolog 3 | 6.5 | 1.5 | 1.5 | 2.0 | ||||||||
| Bmp2 | Bone morphogenetic protein 2 | 5.3 | |||||||||||
| Apln | Apelin | 4.7 | 6.1 | 7.4 | 0.7 | ||||||||
| Thbs2 | Thrombospondin 2 | 4.1 | 0.4 | 0.4 | 1.9 | 1.1 | 7.8 | ||||||
| Thbs3 | Thrombospondin 3 | 3.6 | |||||||||||
| Il1b | Interleukin 1 beta | 3.5 | 0.06 | 0.06 | 0.4 | ||||||||
| Pgf | Placental growth factor | 3.4 | 13.2 | 16.8 | 0.8 | ||||||||
| Ace | Angiotensin I converting enzyme 1 | 3.2 | 1.4 | 1.6 | 1.6 | 2.2 | 2.2 | 1.8 | |||||
| Lif | Leukemia inhibitory factor | 3 | 0.8 | 0.8 | 0.7 | ||||||||
| Bmp4 | Bone morphogenetic protein 4 | 2.7 | 9.4 | 3.5 | 1.6 | 0.6 | |||||||
| Tnxb | Tenascin XB | 2.7 | 0.8 | 0.5 | |||||||||
| Wisp1 | WNT1 inducible signaling pathway protein 1 | 2.6 | 0.8 | 0.4 | 0.9 | 1.9 | |||||||
| Mdk | Midkine | 2.5 | 2.3 | 1.8 | 0.9 | 0.5 | |||||||
| Adm | Adrenomedullin | 2.1 | 0.3 | 0.4 | 1.2 | 2.6 |
(A) Relative expression of angiocrine proteins in cardiac microvascular ECs of mice after thoracic aortic constriction compared to sham operated mice; microarray data of flow cytometry sorted cardiac microvascular ECs (n = 1) (Moore-Morris et al., 2014). (B) Relative expression in various EC cultures (n = 14) compared to various fibroblast cultures (n = 7). (C) Relative expression in various EC cultures (n = 14) compared to various smooth muscle cell cultures (n = 26). (D,E) Relative expression in myocardium of rats with hypertensive cardiomyopathy compared to control animals. (F) Relative expression in myocardium of apelin-KO mice compared to control. (G,H) Relative expression in remote myocardium after myocardial infarction. (I) Relative expression in obesity-induced heart failure in mice compared to controls. (J) Relative expression in myocardial biopsy samples of patients with dilated cardiomyopathy compared to normal cardiac samples (Barth et al., 2006). (K) Relative expression in myocardium of pacing induced heart failure in dogs compared to control samples. (L) Relative expression in myocardial biopsy samples of patients with myocarditis compared to normal cardiac samples. Column B–L: only significant differences are shown.