Table 5.
Expression of extracellular matrix proteins by endothelial cells during cardiac overload.
| Gene | Protein | Fold |
|---|---|---|
| COLLAGEN | ||
| Col1a1 | collagen, type I, alpha 1 | 44.7 |
| Col1a2 | collagen, type I, alpha 2 | 59.4 |
| Col3a1 | collagen, type III, alpha 1 | 38.4 |
| Col4a4 | collagen, type IV, alpha 4 | 5.6 |
| Col5a1 | collagen, type V, alpha 1 | 13.3 |
| Col5a2 | collagen, type V, alpha 2 | 20.6 |
| Col6a1 | collagen, type VI, alpha 1 | 16.0 |
| Col6a2 | collagen, type VI, alpha 2 | 7.7 |
| Col6a3 | collagen, type VI, alpha 3 | 16.5 |
| Col8a1 | collagen, type VIII, alpha 1 | 8.1 |
| Col8a2 | collagen, type VIII, alpha 2 | 7.1 |
| Col11a1 | collagen, type XI, alpha 1 | 10.0 |
| Col12a1 | collagen, type XII, alpha 1 | 24.6 |
| Col14a1 | collagen, type XIV, alpha 1 | 20.1 |
| Col15a1 | collagen, type XV, alpha 1 | 2.5 |
| Col16a1 | collagen, type XVI, alpha 1 | 4.6 |
| Col18a1 | collagen, type XVIII, alpha 1 | 7.1 |
| Col27a1 | collagen, type XXVII, alpha 1 | 4.6 |
| BASEMENT MEMBRANE COMPONENTS | ||
| Lama2 | laminin, alpha 2 | 6.3 |
| Lamb1 | laminin B1 | 2.3 |
| MAJOR KNOWN EXTRACELLULAR MATRIX GLYCOPROTEINS | ||
| Efemp1 | epidermal growth factor-containing fibulin-like extracellular matrix protein 1 | 2.6 |
| Eln | Elastin | 2.3 |
| Emid2 | EMI domain containing 2 | 5.3 |
| Emilin1 | elastin microfibril interfacer 1 | 3.3 |
| Emilin2 | elastin microfibril interfacer 2 | 3.5 |
| Fbln1 | fibulin 1 | 7.5 |
| Fbln2 | fibulin 2 | 2.5 |
| Fbln5 | fibulin 5 | 2.9 |
| Fbn1 | fibrillin 1 | 3.7 |
| Fbn2 | fibrillin 2 | 8.3 |
| Fn1 | fibronectin 1 | 3.4 |
| Matn2 | matrilin 2 | 5.4 |
| Mfap4 | microfibrillar-associated protein 4 | 45.0 |
| Mfap5 | microfibrillar associated protein 5 | 36.6 |
| Postn | periostin, osteoblast specific factor | 46.7 |
| PROTEOGLYCAN | ||
| Aspn | Asporin | 7.2 |
| Bgn | Biglycan | 8.7 |
| Dcn | Decorin | 7.3 |
| Fmod | Fibromodulin | 14.0 |
| Gpc6 | glypican 6 | 3.5 |
| Lum | Lumican | 21.3 |
| Ogn | Osteoglycin | 23.2 |
| Vcan | Versican | 40.6 |
| MMP | ||
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 7.8 |
| Mmp2 | matrix metallopeptidase 2 | 26.6 |
| Mmp23 | matrix metallopeptidase 23 | 10.7 |
| Timp1 | tissue inhibitor of metalloproteinase 1 | 60.5 |
| Timp2 | tissue inhibitor of metalloproteinase 2 | 3.5 |
| EXTRACELLULAR MATRIX PROTEINS OF BONES, CARTILAGE, AND TEETH | ||
| Dpt | Dermatopontin | 6.4 |
| GROWTH-FACTOR-BINDING-PROTEINS | ||
| Igfbp4 | insulin-like growth factor binding protein 4 | 3.3 |
| Igfbp5 | insulin-like growth factor binding protein 5 | 2.5 |
| Kcp | kielin/chordin-like protein | 4.8 |
| Ltbp2 | latent transforming growth factor beta binding protein 2 | 36.3 |
| CCN FAMILY PROTEINS | ||
| Wisp2 | WNT1 inducible signaling pathway protein 2 | 7.6 |
| ENZYMES | ||
| Expi | extracellular proteinase inhibitor | 3.0 |
| Fuca2 | fucosidase, alpha-L- 2, plasma | 3.1 |
| Hpse | Heparanase | 3.1 |
| Lox | lysyl oxidase | 13.3 |
| Loxl1 | lysyl oxidase-like 1 | 24.5 |
| Loxl2 | lysyl oxidase-like 2 | 13.0 |
| Loxl3 | lysyl oxidase-like 3 | 6.8 |
| OTHER POSSIBLE EXTRACELLULAR MATRIX PROTEINS | ||
| Aebp1 | AE binding protein 1 | 3.3 |
| Cilp | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 18.9 |
| Comp | cartilage oligomeric matrix protein | 8.5 |
| Crispld2 | cysteine-rich secretory protein LCCL domain containing 2 | 5.3 |
| Cthrc1 | collagen triple helix repeat containing 1 | 23.0 |
| Igsf10 | Immunoglobulin superfamily, member 10 | 5.3 |
| Lgi3 | leucine-rich repeat LGI family, member 3 | 2.1 |
| Pcolce | procollagen C-endopeptidase enhancer protein | 4.8 |
| Pcolce2 | procollagen C-endopeptidase enhancer 2 | 6.0 |
| Smoc2 | SPARC related modular calcium binding 2 | 8.7 |
| Spon1 | spondin 1, (f-spondin) extracellular matrix protein | 2.1 |
| Srpx2 | sushi-repeat-containing protein, X-linked 2 | 21.2 |
| Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | 6.8 |
| Tgfbi | transforming growth factor, beta induced | 4.5 |