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Mutual antagonism between aPAR and pPar proteins creates a detachment zone at the interface between aPAR- and pPAR-dominated regions. A region of high aPAR density on the membrane is a detachment zone for pPAR, such that detaching pPARs can only attach to a region of low aPAR density, and vice versa. A balance of the mutual antagonistic processes is necessary to prevent one protein species from dominating over the other and taking over the whole membrane.
