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. 2018 Apr 11;11:121. doi: 10.3389/fnmol.2018.00121

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Copyright © 2018 Zhou, Lv, Wang, Zhang, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GLYX-13 significantly attenuated MK-801-induced impairments in PPI but not the startle response. (A) MK-801 significantly increased the startle amplitude. (B) Effect of GLYX-13 on PPI inhibition of the startle response at different prepulses (4, 8, and 12 dB above background) presented before the startle pulse intensity (120 dB). Data represent the mean ± SEM (n = 12 per group; ^∗∗∗P < 0.001, versus the vehicle 1 + vehicle 2-treated group; ^#P < 0.05 and ^###P < 0.001, versus the MK-801 + vehicle 2-treated group).