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. 2018 Apr 11;11:121. doi: 10.3389/fnmol.2018.00121

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Copyright © 2018 Zhou, Lv, Wang, Zhang, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lentivirus-mediated NR2B knock-down in the dentate gyrus. (A) Experimental procedure for the test schedule. NC siRNA or NR2B siRNA were microinjected into the hippocampus following a 13-day acclimatization. (B) NC siRNA or NR2B siRNA were well-expressed in the hippocampal DG regions as indicated by the merged images, which include nuclear staining with DAPI (blue) and green fluorescent protein (GFP, green) observed under a fluorescence microscope. Scale bars = 200 μm. (C,D) The expression of NR2B was significantly decreased by NR2B siRNA in the hippocampus of mice. Data are expressed as means ± SEM (n = 3; ^∗∗P < 0.01 compared with NC siRNA group).