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. 2018 Apr 11;9:615. doi: 10.3389/fimmu.2018.00615

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Copyright © 2018 Batista, Alvarado-Arnez, Alves, Melo, Pereira, Ruivo, da Silva, Gibaldi, da Silva, de Lorena, de Melo, de Araújo Soares, Barros, Costa, Cardoso, Pacheco, Carrazzone, Oliveira, Moraes and Lannes-Vieira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of CCR5 deficiency on survival and myocardial injury in T. cruzi-infected mice. Mice were infected with 1,000 trypomastigote forms of the Colombian T. cruzi strain and analyzed at 70 days postinfection. (A) Survival curves of T. cruzi-infected Ccr5⁺/⁺ and Ccr5^−/− mice. Deaths were registered weekly. (B) Sera were collected, and CK-MB activity was determined by biochemical assay. Data represent two independent experiments with three noninfected (NI) and five to seven infected mice [*P < 0.05, T. cruzi-infected Ccr5^+/+ mice vs NI; ^#P < 0.05, Ccr5^−/− vs Ccr5^+/+ T. cruzi-infected mice (analysis of variance, Bonferroni posttest)].