Table 4.
Biological activities of compounds 1–8.
| Compounds | Antimicrobial activity MIC (µg/mL) | Nematicidal activity LD90 (µg/mL) | Antifungal activity (% growth inhibition at ≤ 12.5 µg/mL) | |
|---|---|---|---|---|
| Bacillus subtillis DSM10 | Mucor plumbeus MUCL 49355 | Caenorhabditis elegans | Phellinus tremulae CBS 123.40 | |
| Thailanone A (1) | ≤ 50 | – | ≤ 50 | 50 |
| Thailanone B (2) | – | – | ≤ 25 | 28.6 |
| Thailanone C (3) | – | – | ≤ 25 | 31.4 |
| Thailanone D (4) | – | ≤ 25 | ≤ 12.5 | 28.6 |
| Thailanone E (5) | – | – | ≤ 50 | 25. |
| Thailanone F (6) | – | – | ≤ 25 | 41.4 |
| Monocerin (7) | – | – | – | 28.6 |
| Deoxyphomalone (8) | ≤ 12.5 | ≤ 25 | ≤ 12.5 | 50 |
| Standards | ||||
| Nystatin # | – | ≤ 0.782 | – | 100 |
| Ciprofloxacin †† | ≤ 0.78 | – | – | – |
| Ivermectin ‡‡ | – | – | ≤ 12.5 | – |
| Methanol | – | – | – | – |
No activity against Candida tenuis, Setaria italica and Lepidum sativum was observed for any of tested compounds up to concentrations of 100 µg/mL. # Nystatin-antifungal reference; †† Ciprofloxacin-antibacterial reference; ‡‡ Ivermectin-nematicidal reference.