Table 2.
Estimates for the mixed linear model
| Effect | Estimate | Lower 95% CL* | Upper 95% CL | P‐value |
|---|---|---|---|---|
| Tryptophan | ||||
| Intercept (µmol/l) | 52·59 | 40·04 | 65·15 | <·001 |
| Therapy (bel † versus tac ‡ ) (µmol/l) | −1·10 | −15·47 | 13·26 | 0·873 |
| Days (µmol/l day) | 0·16 | −0·32 | 0·63 | 0·512 |
| Days × therapy (bel versus tac) (µmol/l day) | −0·13 | −0·68 | 0·41 | 0·632 |
| MMF (yes versus no) | 12·25 | −2·93 | 27·42 | 0·107 |
| Kynurenine | ||||
| Intercept (µmol/l) | 2·69 | 1·83 | 3·55 | < 0·001 |
| Therapy (bel versus tac) (µmol/l) | −0·24 | −1·23 | 0·75 | 0·613 |
| Days (µmol/L day) | 0·00 | −0·03 | 0·03 | 0·960 |
| Days × therapy (bel versus tac) (µmol/l day) | −0·01 | −0·04 | 0·02 | 0·471 |
| MMF (yes versus no) | 0·61 | −0·54 | 1·76 | 0·279 |
| Kynurenine/tryptophan ratio | ||||
| Intercept (µmol/l) | 55·78 | 34·95 | 76·61 | < 0·001 |
| Therapy (bel versus tac) (µmol/l) | −4·95 | −28·84 | 18·94 | 0·668 |
| Days (µmol/l day) | −0·25 | −1·00 | 0·51 | 0·519 |
| Days × therapy (bel versus tac) (µmol/l day) | 0·02 | −0·86 | 0·89 | 0·969 |
| MMF (yes versus no) | 0 | −26·39 | 22·98 | 0·886 |
*Confidence limit; †belatacept; ‡tacrolimus. MMF = mycophenolate mofetil.