Table 1.
Basic immunodeficient murine background strains for xenotransplantation
| Name abbreviation | Strain name | Details | Reference |
|---|---|---|---|
| scid | Prkdc scid−/− | Lacks B and T cells due to Prkdc deficiency | 16 |
| NOD.scid | NOD.CB17‐Prkdc scid | Lacks B and T cells due to Prkdc deficiency | 4, 17, 18 |
| NOD SIRPa gene aids in preventing murine phagocytosis of donor HSC | |||
| NSG | NOD.Cg‐Prkdcscid Il2rgtm1WjI | NOD SIRPa gene aids in preventing murine phagocytosis of donor HSC | 19, 22 |
| Lacks B and T cells due to Prkdc deficiency | |||
| IL2rg deficiency prevents NK cell development | |||
| NRG | NOD.Cg‐Rag1 tm1Mom Il2rg tm1Wjl | NOD SIRPa gene aids in preventing murine phagocytosis of donor HSC | 23 |
| Rag1 deficiency prevents recombination and thus maturation of B and T cells | |||
| IL2rg−/−deficiency prevents NK cell development | |||
| NOG | NOD/Shi‐scid IL2rg −/− | NOD SIRPa gene aids in preventing murine phagocytosis of donor HSC | 8, 24 |
| Contains non‐functional truncated IL2rg, resulting in stunted maturation of B and T cells |
HSC, haematopoietic stem cell; IL‐2, interleukin‐2; SIRPa, signal regulatory protein α gene.