Table 1.
Histopathological scores to quantify changes in different organ systems
| Organ | Criterion | Score | ||||
|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | ||
| Bone marrow | Ratio myelopoiesis/erythropoiesis | 3–4 : 1 | 5 : 1 | 6–10 : 1 | 11–25 : 1 | > 25 : 1 |
| Spleen | % increase in extramedullary haematopoiesis | No increase | < 25 | 26–50 | 51–75 | 76–100 |
| Colon | Inflammation | No pathological change | Mild infiltrates of inflammatory cells in the lamina propria without erosion/ulceration | Marked inflammation and deep ulceration with crypt abscesses | Additional epithelial dysplasia and/or neoplasia | – |