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. 2018 Apr 4;2018:8031328. doi: 10.1155/2018/8031328

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Copyright © 2018 Milan Jovanovic et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(a) Decreased fecal IL-1β and systemic TNF-α, while increased fecal Gal-3 and systemic Gal-3/TNF-α ratios in patients with detectable liver metastasis. Patients with CRC were divided into two groups, based on the presence of liver metastasis (+ and −). (b) Decreased fecal IL-1β and systemic TNF-α, while increased fecal Gal-3 and systemic Gal-3/TNF-α ratios in patients with detectable lung metastasis. The patients with CRC were divided into two groups, based on the presence of lung metastasis (+ and −). (c) Decreased fecal IL-1β and systemic TNF-α, while increased fecal Gal-3 and systemic Gal-3/TNF-α ratios in patients with detectable peritoneal carcinomatosis. The patients with CRC were divided into two groups, according to the presence of carcinomatosis in peritoneum cavity (+ and −). The serum levels of all mentioned biomarkers were determined by ELISA. Gal-3/TNF-α ratio was evaluated for each patient, separately. The statistical significance was tested by Mann–Whitney Rank Sum test.