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. Author manuscript; available in PMC: 2018 Apr 18.
Published in final edited form as: Expert Rev Mol Diagn. 2017 Feb 20;17(4):379–391. doi: 10.1080/14737159.2017.1293525

Figure 1.

Figure 1

Simplified diagram of cervical carcinogenesis. The cell of origin infected initially by human papillomavirus (HPV) types influences the manifestation of HPV mediated carcinogenesis. Squamous-type lesions emerge from the cervix squamous-columnar junction (SCU) into low-grade cervical lesions (cervical intraepithelial neoplasia grade 1, CIN1), which may or may not progress to precancerous lesions (cervical intraepithelial neoplasia grade 3, CIN3); alternatively, glandular-type lesions have a poorly detected preinvasive stage (adenocarcinoma in situ, AIS). These lesions will evolve into either squamous cell carcinoma (SCC) or into adenocarcinoma (AC).