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Knockdown of profilin-1 attenuated AGE-induced cell damage and ROS production. HUVECs were transfected with control siRNA (NC) and profilin-1 siRNA (si-profilin-1) for 24 h and then stimulated with AGEs for 24 h. (a) Western blotting demonstrated the expression of profilin-1, T-RhoA, p-RhoA, p-eNOS, and ROCK1. (b) Intracellular ROS, (c) apoptosis, (d) tube formation, and (e) migratory abilities were detected as indicated. ∗∗P < 0.01.
