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Profilin-1 aggravated cell damage and ROS production under AGEs. Stable overexpression of profilin-1 in HUVECs was treated with 50 μg/ml AGEs for 24 h. (a) The effects of profilin-1 on the expression of T-RhoA, p-RhoA, p-eNOS, and ROCK1 were detected by Western blotting. (b) Intracellular ROS, (c) apoptosis, (d) tube formation, and (e) migratory abilities were detected in HUVECs stimulated with 50 μg/ml AGEs for 24 h. ∗∗P < 0.01.
