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RhoA/ROCK1 activation mediated profilin-1-induced cell damage and ROS production. HUVECs stably overexpressing profilin-1 were treated with 5 μg/ml CT-04 or 10 μM Y-27632 for 24 h. (a) Expression of profilin-1, T-RhoA, p-RhoA, p-eNOS, and ROCK1 was determined by Western blot. (b) Intracellular ROS, (c) apoptosis, (d) tube formation, and (e) migratory abilities were analyzed. ∗P < 0.05; ∗∗P < 0.01.
