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. 2018 Apr 17;15:109. doi: 10.1186/s12974-018-1137-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Contribution of NLRP3 inflammasome activation to isoflurane-induced age-related neuroinflammation. Hippocampus was harvested at 24 h after the anesthesia. a Representative western blot images of NLRP3, caspase-1 P45, caspase-1 P20, ASC, IL-18, IL-1β, cleaved caspase-3, and Iba-1. b–i Graphic presentation of abundance of each protein. All values are expressed as fold changes over the mean values of group YC and are presented as mean ± SD (n ≥ 3). *P < 0.05 compared with the corresponding data of group YC. #P < 0.05 and ##P < 0.05 compared with the corresponding data of group AC