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. 2018 Apr 17;7:7. doi: 10.1186/s13741-018-0084-9
Question 1: In your institution, is it routine to screen patients undergoing surgery to identify those at high risk for POPC?
Answer options Response count Response percentage (%)
Yes 174 48.7
No 183 51.3
Question 2: If institutions were to routinely screen for patients at high risk for POPC and then provide a POPC reduction care bundle, what recommendations would you make for constituents of this care bundle? To be applied PRE-operatively:
Answer options Response count Response percentage (%)
Chlorhexidine mouthwash 155 50.5
Selective oral decontamination (SOD), e.g. anti-microbial paste 34 11.1
Selective digestive decontamination (SDD), e.g. non-absorbable enteral antibiotics and IV antibiotics 24 7.8
Oral care, e.g. toothbrushing, dental hygienist review etc. 147 47.9
Supervised exercise programme, also known as pre-habilitation 140 45.6
Nebulised/inhaled medical therapy 94 30.6
Enteral/intravenous medical therapy 39 12.7
Incentive spirometry or positive end-expiratory pressure valve 197 64.2
Inspiratory muscle training 169 55.0
Question 3: If institutions were to routinely screen for patients at high-risk for POPC and then provide a POPC-reduction care bundle, what recommendations would you make for constituents of this care bundle? To be applied INTRA-operatively:
Answer options Response count Response percentage (%)
Low tidal volume ventilation, e.g. 6–8 mL/kg tidal volumes 286 84.6
Appropriate PEEP 251 74.3
Regular recruitment manoeuvres 141 41.7
Endotracheal tube with subglottic secretion drainage 101 29.9
Nebulised antibiotics 9 2.7
Avoid blood transfusion by tolerating anaemia unless Hb ≤ 70 g/L 193 57.1
Use humidified ventilator circuit 182 53.8
Avoid neuromuscular blockade (NMB) other than short-acting NMB for intubation 147 43.5
Specific methods to evaluate or reverse NMB 117 34.6
Fluid resuscitation using advanced monitoring (EVLWI or lung US) to avoid pulmonary oedema 147 43.5
Avoid hyperoxia (saturations ≥ 99% or PaO2 ≥ 14 kPa) 206 60.9
Anti-sialogogues, e.g. glycopyrronium 40 11.8
Question 4: If institutions were to routinely screen for patients at high risk for POPC and then provide a POPC-reduction care bundle, what recommendations would you make for constituents of this care bundle? To be applied POST-operatively:
Answer options Response count Response percentage (%)
High-flow humidified oxygen via nasal cannulae 158 46.3
CPAP administered via facemask or hood 174 51.0
Extubation directly onto bi-level positive pressure ventilation via face mask in all patients 38 11.1
Extubation directly onto bi-level positive pressure ventilation via face mask in selected patients 105 30.8
Incentive spirometry/regular use of positive end-expiratory pressure valve 187 54.8
Inspiratory muscle training 162 47.5
Specific physical therapy or exercises, additional to ERAS early mobilisation 147 43.1
Avoid use of gastric acid suppression medications 96 28.2
Head of bed elevation 309 90.6
Mini-tracheostomy to permit suctioning of airway secretions 13 3.8
Avoidance of hyperoxia (saturations ≥ 99% or PaO2 ≥ 14 kPa) 194 56.9
Question 5: Would you potentially be interested in assessing the feasibility of using this care bundle approach in patients who are at high risk of POPC in your institution?
Answer options Response count Response percentage (%)
Yes 242 79.1
No 64 20.9
Question 6: Once feasibility has been assessed, might your institution be interested in participating in an international multi-centre clinical trial assessing the effectiveness of a POPC reduction care bundle?
Answer options Response count Response percentage (%)
Yes 239 78.1
No 67 21.9