Table 4.

Genes hypermethylated in promoters with significantly decreased gene expression

Gene symbol	DNA methylation			Gene expression			Correlation analysis
	Probe ID	DNAm β diff. (%)	Adjusted P value (< 0.25)	Probe ID	FC	P value (< 0.05)	Spearman’s rank correlation coefficient	P value (< 0.05)
UCN	cg20442078	5.6	0.17	8051061	− 1.12	3.61E−02	− 8.42E−01	2.23E−03
CCHCR1	cg00160818	1.9	0.17	8124868	− 1.14	1.73E−02	− 7.45E−01	9.21E−03
CRB3	cg14782015	4.3	0.20	8025041	− 1.13	1.84E−02	− 7.21E−01	1.21E−02
AGBL4	cg21834207	3.2	0.13	7915971	− 1.17	1.29E−02	− 6.73E−01	1.97E−02
INSL3	cg10174482	4.2	0.13	8035345	− 1.13	4.94E−02	− 6.36E−01	2.72E−02
ANKRD30B	cg21293934	11.2	0.21	8069499	− 1.17	2.24E−02	− 6.08E−01	3.11E−02
FADS1	cg16213375	3.6	0.16	7948612	− 1.8	9.55E−04	− 5.88E−01	4.01E−02
PAPL	cg18481683	2.3	0.24	8028570	− 1.19	1.45E−02	− 5.52E−01	5.21E−02
MOGAT1	cg12678667	4	0.15	8048725	− 1.28	3.87E−02	− 4.67E−01	8.91E−02
PPP1R1B	cg09762778	5	0.12	8006865	− 1.27	4.74E−02	− 4.67E−01	8.91E−02
PRUNE2	cg00390775	4.4	0.15	8161884	− 1.31	1.91E−02	− 3.82E−01	1.39E−01
CIDEA	cg18309817	1.8	0.18	8020211	− 1.32	3.21E−02	− 2.97E−01	2.03E−01
PCYT2	cg19583655	6.2	0.21	8019280	− 1.26	6.38E−04	− 1.88E−01	3.04E−01
SCUBE1	cg07697597	1.7	0.23	8076586	− 1.23	9.03E−03	− 4.24E−02	4.59E−01

FC fold change, DNAm β diff. DNAm β difference