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. 2018 Apr 17;11:18. doi: 10.1186/s13072-018-0187-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Effect of HP1γ KO on TAC-induced differential gene expression. a Principle component analysis. RNA-seq was performed purified CMs after TAC. Three independent biological samples were used for each group: Sham-control (fl/fl), Sham-HP1γ KO (Cre;fl/fl), TAC-control and TAC-HP1γ KO. b MA plot. Y-axis shows fold change of gene expression in HP1γ KO (Cre;fl/fl) vs control (fl/fl). X-axis shows average of count per million in all samples. Significantly, differentially expressed genes are shown in color (up regulation in red and down regulation in green). c RT-qPCR validation. Uniquely upregulated genes in HP1γ KO only after TAC were confirmed by RT-qPCR. *p < 0.05