Table 3.
Ratios of the levels of selected cytokines in sera from treated vs. untreated animals
| Cytokine | Tumor-bearing | Expression | Healthy |
|---|---|---|---|
| IL-1α | 2.7 | Activated Macrophages | 0.86 |
| IL-12p70 | 3.5 | Dendritic cells and macrophages | No change |
| IL-16 | 4 | Released by lymphocytes | 0.57 |
| IL-27 | 4.5 | Antigen-presenting cells, promotes Th1 responses | 0.55 |
| IL-28 | 4.3 | Augments IFN-γ release, cytotoxic potential of CD8+ T cells | High* |
| IL-31 | 3.5 | Activated Th2 T cells | High* |
| MIP-2/CXCL2 | ~ 6 | Secreted by monocytes and macrophages | No change |
| Pentraxin3 | ~ 4 | Mononuclear phagocytes, dendritic cells and neutrophils | 0.21 |
| SPARC | ~ 5 | Osteoblasts, macrophages at site of wound repair | No change |
| TIMP-2 | 3 | Metastasis suppressor, expressed by monocytes, placenta | 0.45 |
| TNFα | 45* | Activated monocytes and macrophages | 0.21 |
| TLR2 | 4.2 | Activated monocytes, DCs, macrophages, B and T cells | 0.37 |
| Lymphotoxin-α | 12.5* | Produced by Th1 T cells | 0.74 |
| sHVEM | ~ 2 | Activated monocytes and lymphocytes | 10 |
| IFN-γ | High* | Activated lymphocytes | No change |
| CCL1 | 2.5 | Activated T cells | No change |
| Lymphotactin | ~ 3 | Activated CD8+ cells | 2.6 |
Markers of lymphocyte and monocyte activation in response to 0.1 nmole/g svL4 in Balb/c mice bearing breast tumors are compared with healthy mice. Sera from three animals were pooled for analysis with an array of 308 soluble factors. (*In these samples, the control value was negligible or low, thus the fold increase for treated samples appears high)