Table 3.

Multivariable logistic regression analysis to evaluate improvement in CKD stage classification provided by CKD risk alleles

Model	Variables	AUC (95% CI)	P	Difference in AUC versus Model 1	P versus Model 1
Model 1 (Clinical)	Age & Gender	0.80 (0.75–0.84)	<  0.0001
Model 2 (Clinical + Biochemical)	Age & Gender  + FGF23 + Vitamin D3	0.92 (0.89–0.95)	<  0.0001	0.12	0.0003
Model 3 (Clinical + Biochemical + Genetic)	Age & Gender  + FGF23 + Vitamin D3  + rs4821480 + rs4821481	0.93 (0.90 to 0.95)	< 0.0001	0.13	0.0001
Model 4 (Clinical + Biochemical + Genetic)	Age & Gender  + FGF23 + Vitamin D3  + rs4821480	0.93 (0.89 to 0.95)	< 0.0001	0.13	0.0001