Table 1.
DCSMDA was applied to case studies of three important cancers. In total, 10, 9 and 8 of the top 10 predicted pairs for these diseases were confirmed based on recent experimental studies
| Disease | miRNA | Evidence (PMID and PMCID) |
|---|---|---|
| Prostatic Neoplasms | hsa-mir-15a | PMID: 25418933 |
| Prostatic Neoplasms | hsa-mir-15b | PMID: 24661838 |
| Prostatic Neoplasms | hsa-mir-16 | PMID: 21880514 |
| Prostatic Neoplasms | hsa-mir-195 | PMID: 26080838 |
| Prostatic Neoplasms | hsa-mir-424 | PMID: 27820701 |
| Prostatic Neoplasms | hsa-mir-497 | PMID: 23886135 |
| Prostatic Neoplasms | hsa-mir-125a | PMCID: PMC3979818 |
| Prostatic Neoplasms | hsa-mir-106b | PMID: 26124181 |
| Prostatic Neoplasms | hsa-mir-17 | PMCID: PMC3008681 |
| Prostatic Neoplasms | hsa-mir-93 | PMID: 26124181 |
| Lung Neoplasms | hsa-mir-15a | PMID: 26314859 |
| Lung Neoplasms | hsa-mir-195 | PMID: 25840419 |
| Lung Neoplasms | hsa-mir-424 | PMID: 27666545 |
| Lung Neoplasms | hsa-mir-497 | PMCID: PMC4537005 |
| Lung Neoplasms | hsa-mir-16 | PMID: 21192009 |
| Lung Neoplasms | hsa-mir-15b | Unconfirmed |
| Lung Neoplasms | hsa-mir-125a | PMID: 24044511 |
| Lung Neoplasms | hsa-mir-106a | PMID: 18328430 |
| Lung Neoplasms | hsa-mir-106b | PMID: 18328430 |
| Lung Neoplasms | hsa-mir-93 | PMID: 24037530 |
| Leukaemia | hsa-mir-424 | PMID: 27013583 |
| Leukaemia | hsa-mir-195 | PMCID: PMC4713510 |
| Leukaemia | hsa-mir-16 | PMID:22912766 |
| Leukaemia | hsa-mir-15a | PMID: 24392455 |
| Leukaemia | hsa-mir-15b | PMCID: PMC4577143 |
| Leukaemia | hsa-mir-497 | Unconfirmed |
| Leukaemia | hsa-mir-125a | PMID: 22456625 |
| Leukaemia | hsa-mir-19b | PMID: 28765931 |
| Leukaemia | hsa-mir-19a | PMID: 28765931 |
| Leukaemia | hsa-mir-17 | PMID: 20439436 |